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24-10-2024
I Maser, M Stebegg-Wagner, A Schirmer, B Bauer, C Amerhauser, M Zulley ... H Loferer, S Bissinger
OMX-0407, a spectrum selective kinase inhibitor shows preclinical and clinical efficacy in Angiosarcoma, an indication of high unmet medical need
14-05-2024
C Hartl, J Zantow, K Heinig, I Maser, M Stebegg-Wagner, S Friedrich, J Schilz ... M Aigner, A Marziale, S Bissinger
IOMX-0675, a LILRB1 and LILRB2 cross-specific antibody, effectively repolarizes immunosuppressive myeloid cells and activates T cells leading to potent tumor cell killing
17-04-2024
I Maser, M Stebegg-Wagner, B Bauer, A Schirmer, M Zulley, F Konstantinidis ... H Loferer, S Bissinger
OMX-0407, a spectrum-selective kinase inhibitor drives cell-cycle arrest in vitro and in vivo – an in-depth MoA analysis by phospho-proteomics
16-04-2024
V Volpin, C Amerhauser, C Tschulik, L Majunke, A Weglarz, K Baritz ... T Michels, N Khandelwal
iOTarg screening platform reveals novel mechanisms of colorectal cancer evasion from antigen-specific tumor cell killing by T cells
05-11-2023
I Maser, S Lacher, M Stebegg, V Piras, B Kracher, K Quirin, M Yule, H Loferer and S Bissinger
Development of a gene signature to predict the anti-tumor response of the salt-inducible kinase (SIK) inhibitor OMX-0407
16-04-2023
I Maser, S Lacher, V Piras, B Kracher, K Zanziger, M Yule, H Loferer and S Bissinger
Development of a gene signature as a biomarker for prediction of response to the salt-inducible kinase (SIK) inhibitor OMX-0407
13-04-2022
I Maser, C Hartl, T Michels, R Milde, V Klein, M Maraslis, P Beckhove, N Khandelwal, M Yule, H Loferer and S Bissinger
OMX-0407, a highly potent SIK3 inhibitor, sensitizes tumor cells to cell death and eradicates immune-checkpoint resistant tumors synergistically in combination with PD-1 inhibition
22-06-2020
T Michels, S Bissinger, P Sennhenn, H Loferer, C Martins Freire, O Reidell, S Meier-Ewert, A Papadimitriou, P Beckhove and N Khandelwal
A first-in-class SIK3 inhibitor, OMX-0370, effectively inhibits tumor growth in syngeneic tumor models, as single agent, by abolishing tumor resistance to immune-derived TNF
26-09-2019
T Michels, A Sorrentino, AN Menevse, S Bissinger, P Sennhenn, V Volpin, S Genssler, H Loferer, C Kohler, R Spang, M Rheli, C Schmidl, M Breinig, M Boutros, S Meier-Ewert, A Papadimitriou, P Beckhove and N Khandelwal
Salt-inducible kinase 3 facilitates tumor cell resistance against cytotoxic T cell attack by shifting TNF signaling from apoptosis to survival
26-09-2019
M Aigner, S Genssler, A Rathinasamy, S Urlinger, J Zantow, S Bissinger, T Michels, S Braendle, R Milde, J Regula, A Papadimitriou, P Beckhove and N Khandelwal
Inhibition of novel immune-checkpoint IGSF11 mediates efficient tumor cell killing in vitro and in vivo